6-苄基-5,6,7,8-四氢吡啶并[4,3-d]嘧啶-4(3H)-酮合成路线 （共 7 条）
反应条件
1: With sodium methylate in methanol T=85°C; 16 h; in sealed vessel; 2: With sodium hydroxide in water T=0°C; 3: With acetic acid in water pH=7;
参考文献
US2006/258689 A1, ;
Page/Page column 22; 23; 27; 28 ;
反应条件
ethanol; sodium ethanolate Reflux;
参考文献
WO2013/54185 A1, ;
Page/Page column 44 ;
反应条件
in 2-methoxy-ethanol Heating / reflux;
参考文献
WO2004/14384 A2, ;
Page/Page column 198-199 ;
WO 2004/014384 A2
反应条件
sodium ethanolate in ethanol Reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 11 p. 3124 - 3132
反应条件
1: With N,N-dimethyl-formamide; trichlorophosphate in acetonitrile T=70°C; 1 h; 2: With sodium hydrogencarbonate in dichloromethane; water T=0°C;
参考文献
RENOVIS, INC.
Patent: WO2008/123963 A1, 2008 ;
Location in patent: Page/Page column 44 ;
WO 2008/123963 A1
反应条件
formic acid; triethylamine; palladium dihydroxide in methanol T=60 - 65°C; 3.25 h;
参考文献
RENOVIS, INC.
Patent: WO2008/123963 A1, 2008 ;
Location in patent: Page/Page column 45 ;
WO 2008/123963 A1
反应条件
1.1: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 1 h / 70 °C
1.2: Cooling with ice
2.1: 2 h / Reflux
3.1: hydrogen / palladium 10 on activated carbon / methanol / 760.05 Torr
View Scheme
参考文献
RENOVIS, INC.
Patent: WO2008/123963 A1, 2008 ;
WO 2008/123963 A1
