1-甲基-1H-吲唑-5-羧酸甲酯合成路线 （共 4 条）
反应条件
1: 1H-indazole-5-carboxylic acid methyl ester With sodium hydride in N,N-dimethyl-formamide; oil T=20°C; 1 h; 2: methyl iodide in N,N-dimethyl-formamide; oil T=20°C;
参考文献
PFIZER, INC.
Patent: WO2009/144554 A1, 2009 ;
Location in patent: Page/Page column 48 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20 - 50°C;
参考文献
WO2009/144554 A1, ;
Page/Page column 49 ;
反应条件
triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride T=100°C; 24 h; Product distribution / selectivity;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 38 ;
US 20120277224 A1
反应条件
1: With sodium hydroxide in methanol T=65°C; 2 h; 2: With hydrogenchloride in water pH=3; Product distribution / selectivity;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 38 ;
US 20120277224 A1
