3-[5-(三氟甲基)-1,2,4-噁二唑-3-基]苯甲酸合成路线 (共 3 条)
反应条件
pyridine T=0 - 50°C; 3 h;
参考文献
TEMPERO PHARMACEUTICALS, INC.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; BALOGLU, Erkan
Patent: WO2013/6408 A1, 2013 ;
Location in patent: Page/Page column 39; 40 ;
反应条件
pyridine 3 h; Reflux;
参考文献
Liu, Kun; Lu, Hong; Hou, Ling; Qi, Zhi; Teixeira, Catia; Barbault, Florent; Fan, Bo-Tao; Liu, Shuwen; Jiang, Shibo; Xie, Lan
Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 7843 - 7854
反应条件
1: sodium carbonate; 8-hydroxy-quinoline; hydroxylamine hydrochloride / ethanol; water / 4 h / |Reflux 2: pyridine / 3 h / 0 - 50 °C View Scheme