反应条件
1: 6-Bromo-3,4-dihydro-1H-quinolin-2-one With potassium tert-butylate in N,N-dimethyl-formamide
T=0°C; 0.25 h;
2: methyl iodide in N,N-dimethyl-formamide
T=0 - 20°C;
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; FANTASIA, Serena Maria; HORNSPERGER, Benoit; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander, V.; MOHR, Peter; SCALONE, Michelangelo; TAN, Xuefei; ZHOU, Mingwei
Patent: WO2013/41591 A1, 2013 ;
Location in patent: Page/Page column 64 ;
