3-[(E)-2-丁酰基]-1,3-噁唑烷-2-酮合成路线 （共 8 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 1.16667 h;
参考文献
Bull, Steven D.; Davies, Stephen G.; Garner, A. Christopher; Kruchinin, Dennis; Key, Min-Suk; Roberts, Paul M.; Savory, Edward D.; Smith, Andrew D.; Thomson, James E.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 15 p. 2945 - 2964
反应条件
triethylamine; lithium chloride in tetrahydrofuran
参考文献
Velthuisen, Emile J.; Danishefsky, Samuel J.
Journal of the American Chemical Society, 2007 , vol. 129, # 35 p. 10640 - 10641
反应条件
1: oxazolidin-2-one With n-butyllithium in tetrahydrofuran T=-78°C; deprotonation; 2: crotonic pivalic anhydride in tetrahydrofuran T=-78 - 20°C; Acylation; Further stages.;
参考文献
Soloshonok, Vadim A.; Cai, Chaozhong; Hruby, Victor J.; Van Meervelt, Luc; Yamazaki, Takashi
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6688 - 6696
反应条件
n-butyllithium; Mukayama reagent; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 0.5 h;
参考文献
Matsuo, Jun-Ichi; Aizawa, Yayoi
Tetrahedron Letters, 2005 , vol. 46, # 3 p. 407 - 410
反应条件
2-chloro-1-methyl-pyridinium iodide; triethylamine in dichloromethane 72 h; Heating;
参考文献
Knol, Joop; Feringa, Ben L.
Synthetic Communications, 1996 , vol. 26, # 2 p. 261 - 268
反应条件
1: With (CuOTf)2.C6H6; (2-diphenylphosphinobenzoyl)-Thr(O-t-Bu)-D-Val-NH-n-butyl in toluene T=0°C; 1.3 h; 2: With lithium hydroxide; dihydrogen peroxide in tetrahydrofuran Title compound not separated from byproducts;
参考文献
Hird, Alexander W.; Hoveyda, Amir H.
Angewandte Chemie - International Edition, 2003 , vol. 42, # 11 p. 1276 - 1279
反应条件
bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole-2-yl)cyclopropane; zinc trifluoromethanesulfonate; triethylamine; 4 A molecular sieve in dichloromethane T=20°C; 8 h;
参考文献
Sibi, Mukund P.; Soeta, Takahiro
Journal of the American Chemical Society, 2007 , vol. 129, # 15 p. 4522 - 4523
反应条件
1: With (CuOTf)2.C6H6; (2-diphenylphosphinobenzoyl)-Thr(O-t-Bu)-D-Val-NH-n-butyl in toluene T=0°C; 1.3 h; 2: With lithium hydroxide; dihydrogen peroxide in tetrahydrofuran Title compound not separated from byproducts;
参考文献
Hird, Alexander W.; Hoveyda, Amir H.
Angewandte Chemie - International Edition, 2003 , vol. 42, # 11 p. 1276 - 1279
