4-氯-2,3,5-三甲基吡啶合成路线 （共 8 条）
反应条件
sulfuric acid; hydrogen; palladium on activated charcoal in ethanol T=20°C; P=1500.1 Torr;
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 42, # 8 p. 524 - 529
反应条件
morpholine; 1-methyl-pyrrolidin-2-one T=190°C; 2 h;
参考文献
Tetrahedron Letters, , vol. 28, # 32 p. 3733 - 3736
反应条件
1: 95 percent / phosphoryl chloride / 4 h / 150 °C 2: 78 percent / hydrogen, conc. H2SO4 / 10percent Pd/C / ethanol / 20 °C / 1500.1 Torr View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 42, # 8 p. 524 - 529
反应条件
1: morpholine * HCl / dimethylformamide / 2 h / 150 °C 2: 80 percent / NMP, morpholine / 2 h / 190 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 32 p. 3733 - 3736
反应条件
sodium methylate in water; dimethyl sulfoxide
反应条件
potassium hydroxide in dimethyl sulfoxide T=60°C; 15 h;
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 42, # 8 p. 524 - 529
反应条件
dihydrogen peroxide in acetic acid 1.) 60 deg C, 4 h, 2.) 90 deg C, 2 h;
参考文献
Aktiebolaget Hassle
Patent: US4785113 A1, 1988 ;
反应条件
1: 77 percent / KOH / dimethylsulfoxide / 15 h / 60 °C
2: 95 percent / H2O2 / acetic acid / 30 deg C, 1 h -> 70 deg C, 5 h -> 90 deg C
View Scheme
参考文献
Mittelbach, Martin; Schmidt, Hans-Werner; Uray, Georg; Junek, Hans; Lamm, Bo; et al.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988 , vol. 42, # 8 p. 524 - 529
