4-氯-2,3,5-三甲基吡啶-1-氧化物合成路线 （共 14 条）
反应条件
dihydrogen peroxide in acetic acid 1.) 60 deg C, 4 h, 2.) 90 deg C, 2 h;
参考文献
Aktiebolaget Hassle
Patent: US4785113 A1, 1988 ;
反应条件
acetyl chloride T=-30 - 20°C; 4.33 h; Product distribution / selectivity;
参考文献
Eisai Co., Ltd.
Patent: US2007/10542 A1, 2007 ;
Location in patent: Page/Page column 39 ;
反应条件
sodium acetate; acetic acid in water
反应条件
1: 78 percent / hydrogen, conc. H2SO4 / 10percent Pd/C / ethanol / 20 °C / 1500.1 Torr 2: 83 percent / H2O2 / acetic acid / 1.) 60 deg C, 4 h, 2.) 90 deg C, 2 h View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 42, # 8 p. 524 - 529
反应条件
1: 95 percent / phosphoryl chloride / 4 h / 150 °C 2: 78 percent / hydrogen, conc. H2SO4 / 10percent Pd/C / ethanol / 20 °C / 1500.1 Torr 3: 83 percent / H2O2 / acetic acid / 1.) 60 deg C, 4 h, 2.) 90 deg C, 2 h View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 42, # 8 p. 524 - 529
反应条件
morpholine; 1-methyl-pyrrolidin-2-one T=190°C; 2 h;
参考文献
Tetrahedron Letters, , vol. 28, # 32 p. 3733 - 3736
反应条件
1: in acetic anhydride; toluene T=60 - 95°C; 7 h; 2: With sodium hydroxide in water; toluene T=50°C; 18 h;
参考文献
ALTANA PHARMA AG
Patent: WO2007/12650 A1, 2007 ;
Location in patent: Page/Page column 28 ;
反应条件
methanesulfonyl chloride; lithium chloride in toluene T=0 - 20°C; 993.6 h; Heating / reflux;
参考文献
WO2008/47849 A1, ;
Page/Page column 60; 61 ;
反应条件
1: sodium hydroxide 2: acetic acid / methanol; toluene 3: sodium hydroxide / methanol 4: thionyl chloride View Scheme
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
参考文献
Aktiebolaget Hassle
Patent: US4785113 A1, 1988 ;
