N-Boc-4-羟基哌啶合成路线 （共 171 条）
反应条件
sodium tetrahydroborate in ethanol
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 7 p. 891 - 894
反应条件
sodium hydroxide in water; tert-butyl alcohol T=20°C;
参考文献
WO2004/9550 A1, ;
Page 47 ;
WO 2004/009550 A1
反应条件
sodium hydrogencarbonate in dichloromethane 15 h;
参考文献
WO2004/113297 A2, ;
Page 15 ;
WO 2004/113297 A2
反应条件
carbonic acid di-tert-butyl ester; triethylamine in dichloromethane T=0°C; 21 h;
参考文献
US2003/236416 A1, ;
Page 7 ;
反应条件
triethylamine in tetrahydrofuran; ethyl acetate
参考文献
US6372758 B1, ;
US 6372758 B1
反应条件
triethylamine in tetrahydrofuran; ethyl acetate
参考文献
US6372758 B1, ;
US 6372758 B1
参考文献
US2003/171370 A1, ;
US 20030171370 A1
反应条件
D-glucose; cells of Sphingomonas sp. HXN-200 in phosphate buffer T=30°C; pH=8.0; 2 h;
参考文献
Organic Letters, , vol. 4, # 11 p. 1859 - 1862
反应条件
1: C18H26BrN3O4 With trifluoroacetic acid in dichloromethane 0.5 h; 2: C13H18BrN3O2; tert-butyl 4-oxo-piperidine-1-carboxylate With sodium tris(acetoxy)borohydride; triethylamine in 1,2-dichloro-ethane T=20°C; 16 h; 3: With water; sodium hydrogencarbonate in dichloromethane; 1,2-dichloro-ethane
参考文献
WO2008/8453 A1, ;
Page/Page column 66 ;
WO 2008/008453 A1
反应条件
sodium cyanoborohydride; acetic acid in methanol T=60°C; 16 h;
参考文献
WO2008/70758 A1, ;
Page/Page column 31 ;
WO 2008/070758 A1
