6-甲基-8-(甲基硫代)-咪唑并[1,2-a]吡嗪合成路线 （共 3 条）
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=105°C;
参考文献
SCHERING CORPORATION
Patent: WO2008/156614 A2, 2008 ;
Location in patent: Page/Page column 72; 73 ;
WO 2008/156614 A2
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in N,N-dimethyl-formamide
T=100°C;
参考文献
Voss, Matthew E.; Rainka, Matthew P.; Fleming, Mike; Peterson, Lisa H.; Belanger, David B.; Siddiqui, M. Arshad; Hruza, Alan; Voigt, Johannes; Gray, Kimberly; Basso, Andrea D.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3544 - 3549
反应条件
1: methanol / 20 °C
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / N,N-dimethyl-formamide / 100 °C
View Scheme
参考文献
Zeng, Hongbo; Belanger, David B.; Curran, Patrick J.; Shipps Jr., Gerald W.; Miao, Hua; Bracken, Jack B.; Arshad Siddiqui; Malkowski, Michael; Wang, Yan
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5870 - 5875
