3-(二氟甲基)-1-甲基-1H-吡唑-4-羧醛合成路线 (共 3 条)
反应条件
triethylamine tris(hydrogen fluoride) T=150°C; 2 h;
参考文献
EP2008996 A1, ;
Page/Page column 9; 15 ;
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=45 - 50°C; 1.75 h; 2: methyl hydrazine in dichloromethane T=5 - 80°C; 0.5 h; 3: With sodium hydroxide in water pH=9.8; Product distribution / selectivity;
参考文献
EP2008996 A1, ;
Page/Page column 9; 10 ;
反应条件
1: With sodium hydroxide; dihydrogen peroxide in water T=40 - 45°C; 1.5 h; 2: With hydrogenchloride in water pH=2.5; Product distribution / selectivity;
参考文献
EP2008996 A1, ;
Page/Page column 9; 10 ;