1-Boc-5-羟基-3-哌啶甲酸甲酯合成路线 （共 6 条）
反应条件
N-ethyl-N,N-diisopropylamine in 1,4-dioxane T=20°C; 18 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 3095 - 3098
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 3 h / 50 °C 2: platinum(IV) oxide; sulfuric acid; hydrogen / ethanol / 24 h / 20 °C / 2585.81 Torr 3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 18 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 3095 - 3098
反应条件
1: platinum(IV) oxide; sulfuric acid; hydrogen / ethanol / 24 h / 20 °C / 2585.81 Torr 2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 18 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 3095 - 3098
反应条件
sodium hydroxide in methanol 18 h; Reflux;
参考文献
DeNinno, Michael P.; Wright, Stephen W.; Visser, Michael S.; Etienne, John B.; Moore, Dianna E.; Olson, Thanh V.; Rocke, Benjamin N.; Andrews, Melissa P.; Zarbo, Cynthia; Millham, Michele L.; Boscoe, Brian P.; Boyer, David D.; Doran, Shawn D.; Houseknecht, Karen L.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 3095 - 3098
反应条件
1: diethylamino-sulfur trifluoride / dichloromethane / 5.08 h / -78 - 20 °C 2: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C View Scheme
参考文献
GLAXO GROUP LIMITED; Atkinson, Francis Louis; Atkinson, Stephen John; Barker, Michael David; Douault, Clement; Garton, Neil Stuart; Liddle, John; Patel, Vipulkumar Kantibhai; Preston, Alexander G.; Shipley, Tracy Jane; Wilson, David Matthew; Watson, Robert J.
Patent: US2014/5188 A1, 2014 ;
反应条件
sodium hydroxide in methanol
18 h; Reflux;
参考文献
DeNinno, Michael P.; Wright, Stephen W.; Visser, Michael S.; Etienne, John B.; Moore, Dianna E.; Olson, Thanh V.; Rocke, Benjamin N.; Andrews, Melissa P.; Zarbo, Cynthia; Millham, Michele L.; Boscoe, Brian P.; Boyer, David D.; Doran, Shawn D.; Houseknecht, Karen L.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 3095 - 3098
