(2-吡啶-4-基-乙基)氨基甲酸叔丁酯合成路线 (共 9 条)
反应条件
in dichloromethane T=20°C;
参考文献
ELAN PHARMACEUTICALS, INC.
Patent: WO2003/93245 A1, 2003 ;
Location in patent: Page/Page column 147 ;
WO 03/093245 A1
反应条件
in dichloromethane T=20°C;
参考文献
ELIAN PHARMACEUTICALS INC
Patent: WO2004/33436 A1, 2004 ;
Location in patent: Page 59 ;
WO 2004/033436 A1
反应条件
in tetrahydrofuran T=20°C; 1 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/87145 A2, 2004 ;
Location in patent: Page/Page column 31 ;
反应条件
1: 99 percent / H2 / Pd/C / ethanol / 20 °C 2: 63 percent / NaOH / ethanol / 0.5 h / 20 °C 3: 55 percent / diphenylphosphorylazide; triethylamine / 4 h / Heating View Scheme
参考文献
Yoshizawa, Hidenori; Kubota, Tadatoshi; Itani, Hikaru; Minami, Kyoji; Miwa, Hideaki; Nishitani, Yasuhiro
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 4221 - 4231
反应条件
1: 46.9 g / ammonium chloride / H2O; methanol / Heating 2: 2-methyl-propan-2-ol / 12 h / 20 °C View Scheme
参考文献
Steinmetzer, Torsten; Schweinitz, Andrea; Stuerzebecher, Anne; Doennecke, Daniel; Uhland, Kerstin; Schuster, Oliver; Steinmetzer, Peter; Mueller, Friedemann; Friedrich, Rainer; Than, Manuel E.; Bode, Wolfram; Stuerzebecher, Joerg
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4116 - 4126
反应条件
diphenylphosphoranyl azide; triethylamine 4 h; Heating;
参考文献
Yoshizawa, Hidenori; Kubota, Tadatoshi; Itani, Hikaru; Minami, Kyoji; Miwa, Hideaki; Nishitani, Yasuhiro
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 4221 - 4231
反应条件
1: 63 percent / NaOH / ethanol / 0.5 h / 20 °C 2: 55 percent / diphenylphosphorylazide; triethylamine / 4 h / Heating View Scheme
参考文献
Yoshizawa, Hidenori; Kubota, Tadatoshi; Itani, Hikaru; Minami, Kyoji; Miwa, Hideaki; Nishitani, Yasuhiro
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 4221 - 4231
反应条件
hydrogenchloride; hydrogen; platinum(IV) oxide in methanol T=20°C; 18 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/87145 A2, 2004 ;
Location in patent: Page/Page column 31 ;
反应条件
hydrogen; platinum(IV) oxide in acetic acid
P=2999.54 Torr;
参考文献
ELAN PHARMACEUTICALS, INC.
Patent: WO2003/93245 A1, 2003 ;
Location in patent: Page/Page column 147-148 ;
WO 03/093245 A1