(R)-(1-(3-(6-(三氟甲基)-1H-苯并[d]咪唑-2-基)异噁唑-5-基)乙基)氨基甲酸叔丁酯合成路线 （共 2 条）
反应条件
1: (R)-5-(1-(tert-butoxycarbonylamino)ethyl)isoxazole-3-carboxylic acid With triethylamine; isobutyl chloroformate in tetrahydrofuran T=-20°C; 1 h; 2: 4-(trifluoromethyl)-1,2-phenylenediamine in tetrahydrofuran T=-20 - 20°C; 4 h; 3: With water; sodium carbonate; acetic acid more than 3 stages;
参考文献
Sunesis Pharmaceuticals, Inc.
Patent: US2009/36419 A1, 2009 ;
Location in patent: Page/Page column 88 ;
US 20090036419 A1
反应条件
1: With trifluoroacetic acid T=20°C; 2 h; 2: With water; potassium carbonate in ethyl acetate
参考文献
Sunesis Pharmaceuticals, Inc.
Patent: US2009/36419 A1, 2009 ;
Location in patent: Page/Page column 88; 88-89 ;
US 20090036419 A1
