4-苯胺-1-苄基哌啶-4-羧酰胺合成路线 （共 13 条）
反应条件
sulfuric acid 48 h; Ambient temperature;
参考文献
Taber, Douglass F.; Rahimizadeh, Mohammad
Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 4037 - 4038
反应条件
1: 58 percent / aq. AcOH / 48 h / 20 °C 2: 77 percent / H2SO4 / 16 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7720 - 7732
反应条件
1: AcOH / H2O / 48 h / Ambient temperature 2: 90percent H2SO4 / 20 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 16 p. 3169 - 3173
反应条件
1: AcOH / toluene / 20 h / Heating 2: H2, conc. aq. HCl / 5percent Pd/C / methanol / 96 h / 2327.2 Torr 3: Na2CO3 / H2O; dioxane / 20 h / Ambient temperature 4: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 3 h 5: Na2CO3 / methanol; H2O / 3 h / Heating View Scheme
参考文献
Mavunkel, Babu J.; Lu, Zhijian; Goehring, R. Richard; Lu, Songfeng; Chakravarty, Sarvajit; Perumattam, John; Novotny, Elizabeth A.; Connolly, Maureen; Valentine, Heather; Kyle, Donald J.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 16 p. 3169 - 3173
参考文献
Heinrich-Pette-Institut; Julius-Maximilians-Universitaet Wuerzburg
Patent: EP2036556 A1, 2009 ;
Location in patent: Page/Page column 17; 24 ;
反应条件
potassium hydroxide in ethylene glycol T=20 - 210°C; 3 h;
参考文献
Srimurugan, Sankareswaran; Murugan, Kaliyappan; Chen, Chinpiao
Chemical and Pharmaceutical Bulletin, 2009 , vol. 57, # 12 p. 1421 - 1424
反应条件
1.1: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C 2.1: NaH / dimethylformamide 2.2: 42 percent / dimethylformamide / 48 h / 20 °C 3.1: 23 percent / 6 h / Heating View Scheme
参考文献
Henriksen, Gjermund; Platzer, Stefan; Marton, Janos; Hauser, Andrea; Berthele, Achim; Schwaiger, Markus; Marinelli, Luciana; Lavecchia, Antonio; Novellino, Ettore; Wester, Hans-Juergen
Journal of Medicinal Chemistry, 2005 , vol. 48, # 24 p. 7720 - 7732
反应条件
toluene-4-sulfonic acid T=105°C; 36 h;
参考文献
Journal of Organic Chemistry, , vol. 57, # 14 p. 4037 - 4038
反应条件
1.1: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C 2.1: NaH / dimethylformamide 2.2: 42 percent / dimethylformamide / 48 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7720 - 7732
反应条件
1.1: 76 percent / KOH / ethane-1,2-diol / 16 h / 190 °C 2.1: NaH / dimethylformamide 2.2: 42 percent / dimethylformamide / 48 h / 20 °C 3.1: 23 percent / 6 h / Heating 4.1: 52 percent / H2 / Pd/C / ethanol / 24 h / 20 °C View Scheme
参考文献
Henriksen, Gjermund; Platzer, Stefan; Marton, Janos; Hauser, Andrea; Berthele, Achim; Schwaiger, Markus; Marinelli, Luciana; Lavecchia, Antonio; Novellino, Ettore; Wester, Hans-Juergen
Journal of Medicinal Chemistry, 2005 , vol. 48, # 24 p. 7720 - 7732
