4-苯胺-1-苄基哌啶-4-羧酰胺合成路线 （共 13 条）
反应条件
1: With potassium hydroxide; Propylene glycol
27 h; Heating / reflux;
2: With hydrogenchloride in water
T=5 - 10°C; pH=< 1;
3: With sodium hydroxide in water
pH=14;
参考文献
CAMBREX CHARLES CITY, INC.
Patent: WO2008/5423 A1, 2008 ;
Location in patent: Page/Page column 3; 6-7 ;
反应条件
1: conc. HCl / Heating
2: 80 percent / toluene / 240 h / Heating
3: 95 percent / LiAlH4 / tetrahydrofuran; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Jilek, Jiri; Rajsner, Miroslav; Valenta, Vladimir; Borovicka, Milos; Holubek, Jiri; et al.
Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 7 p. 1828 - 1853
反应条件
1: Na2HPO4 / CH2Cl2 / 18 h / 0 - 20 °C
2: 411.2 mg / HCl / H2O / Ambient temperature; 4-5 h
View Scheme
参考文献
Colapret; Diamantidis; Spencer; Spaulding; Rudo
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 968 - 974
