(1,1-二甲基-2-氧代乙基)氨基甲酸叔丁酯合成路线 （共 9 条）
反应条件
pyridine-SO3 complex; triethylamine in dimethyl sulfoxide 0.5 h; Ambient temperature;
参考文献
Seki, Toshimi; Nakao, Tomio; Masuda, Takeshi; Hasumi, Kohichi; Gotanda, Kotaro; Ishimori, Tsutomu; Honma, Seijiro; Minami, Nobuyoshi; Shibata, Kenyu; Yasuda, Kikuo
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 11 p. 2061 - 2069
反应条件
1: With lithium triethylborohydride in tetrahydrofuran T=-40 - 20°C; 1.5 h; 2: With citric acid in tetrahydrofuran; water
参考文献
F.HOFFMANN-LA ROCHE AG
Patent: WO2009/53716 A1, 2009 ;
Location in patent: Page/Page column 69-70 ;
WO 2009/053716 A1
反应条件
sodium hydrogencarbonate; triethylamine in dichloromethane; dimethyl sulfoxide
反应条件
1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 0 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 19 p. 6566 - 6574
反应条件
1: CH2Cl2 / 0 °C 2: SO3*Py / triethylamine; dimethylsulfoxide; CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 6, # 24 p. 3051 - 3056
反应条件
ruthenium(IV) oxide; sodium periodate
参考文献
Casiraghi; Rassu
Synthesis, 1995 , # 6 p. 607 - 626
反应条件
(1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester; potassium carbonate in methanol T=0 - 10°C; 6 h;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2005/19174 A1, 2005 ;
Location in patent: Page/Page column 52-53 ;
反应条件
1: (2-oxo-propyl)-phosphonic acid dimethyl ester With 4-toluenesulfonyl azide; potassium carbonate in acetonitrile T=0°C; 1 h; Inert atmosphere; 2: (1,1-dimethyl-2-oxo-ethyl)-carbamic acid tert-butyl ester in methanol; acetonitrile T=0 - 20°C;
参考文献
Rajagopal, Basker; Chen, Ying-Yu; Chen, Chun-Chi; Liu, Xuan-Yu; Wang, Huei-Ren; Lin, Po-Chiao
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1254 - 1264
