3-氨基-2-溴-4-甲氧基吡啶合成路线 （共 7 条）
反应条件
1: With hydrogenchloride; bromine in water T=20 - 55°C; 2: With ammonium hydroxide in water
参考文献
SANOFI; CHOI-SLEDESKI, Yong Mi; NIEDUZAK, Thaddeus R.; POLI, Gregory B.; SHUM, Patrick Wai-Kwok; STOKLOSA, Gregory T.; ZHAO, Zhicheng
Patent: WO2011/78984 A1, 2011 ;
Location in patent: Page/Page column 62; 63 ;
WO 2011/078984 A1
反应条件
1: hydrogen / palladium 10 on activated carbon / methanol / 5 h / 2068.65 Torr 2: hydrogenchloride; bromine / water / 20 - 55 °C View Scheme
参考文献
SANOFI; CHOI-SLEDESKI, Yong Mi; NIEDUZAK, Thaddeus R.; POLI, Gregory B.; SHUM, Patrick Wai-Kwok; STOKLOSA, Gregory T.; ZHAO, Zhicheng
Patent: WO2011/78984 A1, 2011 ;
WO 2011/078984 A1
反应条件
1: nitric acid; sulfuric acid / 60 h / 70 °C 2: hydrogen / palladium 10 on activated carbon / methanol / 5 h / 2068.65 Torr 3: hydrogenchloride; bromine / water / 20 - 55 °C View Scheme
参考文献
SANOFI; CHOI-SLEDESKI, Yong Mi; NIEDUZAK, Thaddeus R.; POLI, Gregory B.; SHUM, Patrick Wai-Kwok; STOKLOSA, Gregory T.; ZHAO, Zhicheng
Patent: WO2011/78984 A1, 2011 ;
WO 2011/078984 A1
反应条件
Yield given. Multistep reaction;
参考文献
Dehmlow, Eckehard V.; Schulz, Hans-Joachim
Liebigs Annalen der Chemie, 1987 , p. 857 - 862
反应条件
2: 42 percent / NiCl2*6H2O/(C6H5)3P, Zn / 4 h / 50 °C
3: 27 percent / 30percent H2O2, (CH3CO)2O / 14 h / 100 °C
4: 92 percent / Na / 0.25 h / Heating
5: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
View Scheme
参考文献
Dehmlow, Eckehard V.; Schulz, Hans-Joachim
Liebigs Annalen der Chemie, 1987 , p. 857 - 862
反应条件
2: 42 percent / NiCl2*6H2O/(C6H5)3P, Zn / 4 h / 50 °C
3: 27 percent / 30percent H2O2, (CH3CO)2O / 14 h / 100 °C
4: 92 percent / Na / 0.25 h / Heating
View Scheme
参考文献
Dehmlow, Eckehard V.; Schulz, Hans-Joachim
Liebigs Annalen der Chemie, 1987 , p. 857 - 862
反应条件
2: 42 percent / NiCl2*6H2O/(C6H5)3P, Zn / 4 h / 50 °C
3: 27 percent / 30percent H2O2, (CH3CO)2O / 14 h / 100 °C
4: 92 percent / Na / 0.25 h / Heating
5: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
6: 336 h / Irradiation
View Scheme
参考文献
Dehmlow, Eckehard V.; Schulz, Hans-Joachim
Liebigs Annalen der Chemie, 1987 , p. 857 - 862
