1.1: tetrahydrofuran / 0.17 h / 20 °C 1.2: 24 h / 20 °C 2.1: sodium carbonate / water / 0.5 h / 20 °C 3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 21.5 h / 110 °C / Sealed tube 4.1: hydrogen / 5 palladium on charcoal / ethanol / 19 h / 50 °C / 9000.9 Torr 5.1: sodium hydroxide; dihydrogen peroxide / dimethyl sulfoxide / 3.42 h / 0 - 20 °C / Inert atmosphere View Scheme

Multi-step reaction with 2 steps 1.1: ammonium acetate / 4.5 h / 125 °C1.2: 0.5 h / 20 °C2.1: hydrogenchloride; water; iron; anhydrous iron chloride / 2.5 h / 60 - 90 °C