2-(4,4-二甲基-4,5-二氢-2-恶唑基)喹啉合成路线 （共 5 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine; p-toluenesulfonyl chloride in 1,2-dichloro-ethane T=0°C; Inert atmosphereReflux;
参考文献
Sigman, Matthew Scott; Michel, Brian William
Patent: US2011/54176 A1, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
1: BuLi / diethyl ether / -78 °C 2: 1) trimethyltin chloride (Me3SnCl) / 2) (Ph3P)4Pd <tetrakis(triphenylphosphine)palladium(O)> / 1) in Et2O, -78 deg C, 2) C6H6, 12h, reflux View Scheme
参考文献
Dondoni, Alessandro; Fogagnolo, Marco; Fantin, Giancarlo; Medici, Alessandro; Pedrini, Paola
Tetrahedron Letters, 1986 , vol. 27, # 43 p. 5269 - 5270
反应条件
trimethylstannyl chloride; tetrakis(triphenylphosphine) palladium(0) 1) in Et2O, -78 deg C, 2) C6H6, 12h, reflux; Yield given. Multistep reaction;
参考文献
Dondoni, Alessandro; Fogagnolo, Marco; Fantin, Giancarlo; Medici, Alessandro; Pedrini, Paola
Tetrahedron Letters, 1986 , vol. 27, # 43 p. 5269 - 5270
反应条件
1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere; |Schlenk technique 2: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.5 h / 0 °C / |Inert atmosphere; |Schlenk technique 3: triethylamine / dichloromethane / 40 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Zhang, Bo; Zhu, Shou-Fei; Zhou, Qi-Lin
Tetrahedron, 2013 , vol. 69, # 8 p. 2033 - 2037
反应条件
Yield given. Multistep reaction;
参考文献
Dondoni, Alessandro; Fantin, Giancarlo; Fogagnolo, Marco; Medici, Alessandro; Pedrini, Paola
Synthesis, 1987 , # 8 p. 693 - 696
