乙基4-((叔丁基二甲基甲硅烷基)氧基)-1-(2-氯乙基)环己烷羧酸合成路线 (共 2 条)
反应条件
1: Ethyl (cis/trans)-4-lt;(tert-butyldimethylsilyl)oxygt;cyclohexanecarboxylate With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene
T=-78°C; 0.5 h;
2: 1-bromo-2-chloro-ethane in tetrahydrofuran; n-heptane; ethylbenzene
T=-78 - 20°C; 3 h;
参考文献
BIOGEN IDEC MA INC.
Patent: WO2009/9059 A1, 2009 ;
Location in patent: Page/Page column 30-31 ;
WO 2009/009059 A1
反应条件
water; silver nitrate in 1,4-dioxane
0.5 h; Heating / reflux;
参考文献
BIOGEN IDEC MA INC.
Patent: WO2009/9059 A1, 2009 ;
Location in patent: Page/Page column 31 ;
WO 2009/009059 A1