3-亚甲基六氢呋喃并[2,3-b]呋喃合成路线 （共 4 条）
反应条件
tri-n-butyl-tin hydride; 2,2'-azo-bisisobutyronitrile in toluene T=104 - 108°C; 4 h;
参考文献
GLAXOSMITHKLINE LLC; JOHNS, Brian Alvin; TEMELKOFF, David P.; VELTHUISEN, Emile Johann; WEATHERHEAD, Jason Gordon
Patent: WO2011/17395 A1, 2011 ;
Location in patent: Page/Page column 48 ;
反应条件
sodium hydroxide; sodium tetrahydroborate; (pyridine)Co(dimethylglyoxime)2Cl in ethanol
参考文献
Eastham, Stephen A.; Ingham, Steven P.; Hallett, Michael R.; Herbert, John; Modi, Andrea; Morley, Timothy; Painter, James E.; Patel, Prakash; Quayle, Peter; Ricketts, Dean C.; Raftery, James
Tetrahedron, 2008 , vol. 64, # 5 p. 936 - 948
反应条件
1: 1.) O3, 2.) Me2S / 1.) MeOH, CH2Cl2, -78 deg C, 1 h, 2.) MeOH, CH2Cl2, from -78 deg C to RT 2: NaBH4 / ethanol / 2 h / 0 °C View Scheme
参考文献
Journal of medicinal chemistry, , vol. 39, # 17 p. 3278 - 3290
反应条件
1: 1.) O3, 2.) Me2S / 1.) MeOH, CH2Cl2, -78 deg C, 1 h, 2.) MeOH, CH2Cl2, from -78 deg C to RT
2: NaBH4 / ethanol / 2 h / 0 °C
View Scheme
参考文献
Ghosh, Arun K.; Chen, Yan
Tetrahedron Letters, 1995 , vol. 36, # 4 p. 505 - 508
