immobilized lipase PS-30 in dichloromethane; tert-butyl methyl ether T=20°C; 5 h; Resolution of racemateLarge scale reactionEnzymatic reaction; enantioselective reaction;

1: potassium bromide; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite; sodium hydrogencarbonate; tetrabutyl-ammonium chloride / dichloromethane; water / 1 h / 0 °C / |Inert atmosphere; |Large scale 2: sodium tetrahydroborate / dichloromethane; ethanol / 0 °C / |Inert atmosphere 3: acetic anhydride / ethylene glycol dimethyl ether / |Inert atmosphere; |Resolution of racemate; |Large scale View Scheme

immobilized lipase PS-C1 in tert-butyl methyl ether 3 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;