反应条件
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 20 °C / |Large scale 2: N-ethyl-N,N-diisopropylamine; hydrogen; palladium 10 on activated carbon / tetrahydrofuran; isopropyl alcohol / 5.5 h / 40 °C / 1861.76 Torr 3: hydrogenchloride; water / tetrahydrofuran; isopropyl alcohol / 17.5 h / 20 °C 4: hydrogen; palladium 10 on activated carbon / tetrahydrofuran / 7 h / 40 °C / 1861.76 Torr View Scheme
参考文献
Astellas Pharma Inc.; OBITSU, Kazuyoshi; AKIBA, Takahiro; KOBAYASHI, Koji; HIRASAWA, Shun; KONDOH, Yutaka; TAKEGUCHI, Kazuhiro; TAKAHAMA, Yuji; ORII, Ryoki
Patent: EP2669281 A1, 2013 ;
