2-[4-[(4-氯苯基)苯基甲基]哌嗪-1-基]乙醇合成路线 （共 10 条）
反应条件
triethylamine in toluene Heating / reflux;
参考文献
WO2004/103982 A1, ;
Page 15 ;
反应条件
TEA in toluene Alkylation;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 18 p. 2727 - 2730
反应条件
1.1: thionyl chloride / toluene / 1 h / 85 - 90 °C / Large scale reaction 2.1: toluene / 3 h / 80 °C / Large scale reaction 2.2: pH 1 / Large scale reaction 3.1: water / toluene View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 7 p. 1279 - 1282
反应条件
1.1: toluene / 3 h / 80 °C / Large scale reaction 1.2: pH 1 / Large scale reaction 2.1: water / toluene View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 7 p. 1279 - 1282
反应条件
1.1: water; Aliquatreg; 336 / toluene / 20 °C / Large scale reaction 1.2: 5 h / 50 °C / Large scale reaction 2.1: thionyl chloride / toluene / 1 h / 85 - 90 °C / Large scale reaction 3.1: toluene / 3 h / 80 °C / Large scale reaction 3.2: pH 1 / Large scale reaction 4.1: water / toluene View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 7 p. 1279 - 1282
参考文献
Industrie Chimique Belge, , vol. 19, p. 1176,1181
反应条件
1: With potassium hydroxide in DMF (N,N-dimethyl-formamide) T=153°C; 4 - 5 h; 2: With hydrogenchloride in DMF (N,N-dimethyl-formamide); water pH=4.0 - 4.5;
参考文献
Cosma S.p.A.
Patent: US2009/30205 A1, 2009 ;
Location in patent: Page/Page column 4; 5 ;
反应条件
sodium hydroxide in water; dimethyl sulfoxide; toluene T=30 - 35°C; 20 h; Product distribution / selectivity;
参考文献
Cosma S.p.A.
Patent: US2009/30205 A1, 2009 ;
Location in patent: Page/Page column 4; 5 ;
反应条件
1: With sodium hydroxide in water; dimethyl sulfoxide; toluene T=30 - 35°C; 14 - 18 h; 2: With hydrogenchloride in water; acetone T=20°C;
参考文献
Cosma S.p.A.
Patent: US2009/30205 A1, 2009 ;
Location in patent: Page/Page column 3-4 ;
反应条件
1.1: sodium methylate / toluene / 10 - 15 °C / Inert atmosphere; Large scale reaction 1.2: 2 h / 50 - 60 °C / Large scale reaction 2.1: water; sodium hydroxide / 3 h / Reflux; Large scale reaction View Scheme
参考文献
Reiter, Jozsef; Trinka, Peter; Bartha, Ferenc L.; Pongo, Laszlo; Volk, Balazs; Simig, Gyula
Organic Process Research and Development, 2012 , vol. 16, # 7 p. 1279 - 1282
