(R)-2,5-二氢-3,6-二甲氧基-2-异丙基吡嗪合成路线 （共 14 条）
反应条件
in dichloromethane T=20°C; 84 h;
参考文献
Chen, Jianxie; Corbin, Scott P.; Holman, Nicholas J.
Organic Process Research and Development, 2005 , vol. 9, # 2 p. 185 - 187
反应条件
1: 87 percent / N-methylmorpholine, isobutyl chloroformate / tetrahydrofuran; dimethylformamide 2: 1.) H2 / 1.) 10percent Pd/C / 1.) CH3OH, CH2Cl2, 24 h, 2.) toluene, reflux, 12 h 3: 66 percent / CH2Cl2 / 72 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 2 p. 157 - 166
反应条件
1: 1.) H2 / 1.) 10percent Pd/C / 1.) CH3OH, CH2Cl2, 24 h, 2.) toluene, reflux, 12 h 2: 66 percent / CH2Cl2 / 72 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 2 p. 157 - 166
反应条件
1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 16 h / |Reflux 2.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C / |Large scale 3.1: triethylamine / dichloromethane / 0.5 h / |Large scale 3.2: 18 h / 20 °C / |Large scale 4.1: 1,2-dichloro-benzene / 18 h / 175 - 180 °C 5.1: dichloromethane / 84 h / 20 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 9, # 2 p. 185 - 187
反应条件
1.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C / |Large scale 2.1: triethylamine / dichloromethane / 0.5 h / |Large scale 2.2: 18 h / 20 °C / |Large scale 3.1: 1,2-dichloro-benzene / 18 h / 175 - 180 °C 4.1: dichloromethane / 84 h / 20 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 9, # 2 p. 185 - 187
反应条件
1: 1,2-dichloro-benzene / 18 h / 175 - 180 °C 2: dichloromethane / 84 h / 20 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 9, # 2 p. 185 - 187
反应条件
1: 1.) BuLi / 1) THF, hexane, -78 deg C, 15 min; 2) THF, hexane, -78 deg C, 3 h 2: aq. HCl / 48 h View Scheme
参考文献
Raap, J.; Wielen, C. M. van der; Lugtenburg, J.
Recueil des Travaux Chimiques des Pays-Bas, 1990 , vol. 109, # 4 p. 277 - 286
反应条件
1: 83 percent / n-BuLi / tetrahydrofuran / -78 - -20 °C 2: 81 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 20 min, 2.) -78 deg C, 3 h; room temperature, 1 h 3: 53 percent / bis(tricyclohexylphosphine)benzylidene ruthenium dichloride / toluene / 18 h / 100 °C 4: 0.2 M TFA / acetonitrile / 192 h / Ambient temperature View Scheme
参考文献
Cremonesi, Giuseppe; Croce, Piero Dalla; Fontana, Francesco; Rosa, Concetta La
Tetrahedron Asymmetry, 2006 , vol. 17, # 18 p. 2637 - 2641
反应条件
hydrogenchloride; n-butyllithium 1.) -78 deg C, 2.) CH2Cl2/water, room temperature, 2 h; Yield given. Multistep reaction;
参考文献
Mueller, Rudolf; Revesz, Laszlo
Tetrahedron Letters, 1994 , vol. 35, # 24 p. 4091 - 4092
反应条件
Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Zeiss, Hans-Joachim
Tetrahedron Letters, 1987 , vol. 28, # 12 p. 1255 - 1258
