(R)-(+)-1,2-环氧十二烷合成路线 （共 12 条）
反应条件
water; isopropyl alcohol; Jacobsen catalyst (R,R)-salen-Co(OAc) in dichloromethane T=20°C; CoolingInert atmosphere;
参考文献
WO2010/53572 A2, ;
Page/Page column 160 ;
反应条件
[(R,R)-N,N-bis-(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamino-Co(III)-acetate] in dimethylformaldehyde dimethyl acetal; water Jacobsen hydrolytic kinetic resolution; optical yield given as percent ee;
参考文献
Tetrahedron Letters, , vol. 52, # 44 p. 5808 - 5811
反应条件
dihydrogen peroxide; [(S,S-(C6H5)2PCH(CH3)CH(CH3)P(C6H5)2)Pt(pentafluorophenyl)(OH2)]CF3SO3) in dichloromethane T=-10°C; 48 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 128, # 43 p. 14006 - 14007
反应条件
potassium carbonate in methanol T=0 - 20°C;
参考文献
European Journal of Organic Chemistry, , # 30 p. 6886 - 6899
反应条件
potassium carbonate in methanol; dichloromethane T=20°C; 0.5 h;
参考文献
Synthetic Communications, , vol. 38, # 23 p. 4295 - 4313
反应条件
1: di(n-butyl)tin oxide; triethylamine / dichloromethane 2: potassium carbonate / methanol / 0 - 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 30 p. 6886 - 6899
反应条件
sodium methylate in methanol 1 h;
参考文献
Tetrahedron Letters, , vol. 30, # 51 p. 7165 - 7168
反应条件
1: lipase, n-butyl alcohol / hexane / 120 h 2: CH3ONa / methanol / 1 h View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 51 p. 7165 - 7168
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane 2: [(R,R)-N,N-bis-(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamino-Co(III)-acetate] / dimethylformaldehyde dimethyl acetal; water View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 44 p. 5808 - 5811
反应条件
sodium hydroxide; trimethyl-oxonium tetrafluoroborate Yield given. Multistep reaction;
参考文献
Tetrahedron: Asymmetry, , vol. 3, # 9 p. 1149 - 1152
