2,2’-(4-溴-1-亚丁烯基)双[3-甲基噻吩]合成路线 （共 11 条）
反应条件
potassium carbonate; potassium iodide in acetone
参考文献
Zheng, Jianbin; Wen, Ren; Luo, Xiaomin; Lin, Guoqiang; Zhang, Jiange; Xu, Linfeng; Guo, Lihe; Jiang, Hualiang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 225 - 227
反应条件
1: 50 percent / KI, K2CO3 / acetone / 44 h / Ambient temperature 2: 12 M aq. NaOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725
反应条件
hydrogen bromide in acetic acid
T=10°C; 1.5 h;
参考文献
Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725
反应条件
sulfuric acid in isopropyl alcohol
参考文献
Zheng, Jianbin; Wen, Ren; Luo, Xiaomin; Lin, Guoqiang; Zhang, Jiange; Xu, Linfeng; Guo, Lihe; Jiang, Hualiang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 225 - 227
反应条件
1.1: n-BuLi / diethyl ether
1.2: 60 percent / diethyl ether / -70 °C
2.1: 73 percent / H2SO4 / propan-2-ol
View Scheme
参考文献
Zheng, Jianbin; Wen, Ren; Luo, Xiaomin; Lin, Guoqiang; Zhang, Jiange; Xu, Linfeng; Guo, Lihe; Jiang, Hualiang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 225 - 227
参考文献
NOVO NORDISK A/S
Patent: EP236342 B1, 1991 ;
反应条件
1: 1.) Mg / 1.) Et2O, 1 h, 2.) Et2O, 1 h
2: 76 percent / MnO2 / CH2Cl2 / 16 h / Ambient temperature
3: 1.) Mg / 1.) THF, reflux, 0.5 h, 2.) THF, reflux, 1.5 h
4: 46 percent / 48percent aq. HBr / acetic acid / 1.5 h / 10 °C
View Scheme
参考文献
Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725
反应条件
1: 1.) Mg / 1.) THF, reflux, 0.5 h, 2.) THF, reflux, 1.5 h
2: 46 percent / 48percent aq. HBr / acetic acid / 1.5 h / 10 °C
View Scheme
参考文献
Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725
反应条件
1: 76 percent / MnO2 / CH2Cl2 / 16 h / Ambient temperature
2: 1.) Mg / 1.) THF, reflux, 0.5 h, 2.) THF, reflux, 1.5 h
3: 46 percent / 48percent aq. HBr / acetic acid / 1.5 h / 10 °C
View Scheme
参考文献
Andersen, Knud Erik; Braestrup, Claus; Groenwald, Frederik C.; Joergensen, Anker S.; Nielsen, Erik B.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 12 p. 1716 - 1725
反应条件
carbon tetrabromide; triphenylphosphine
参考文献
Herberta, John M.; Mathersa, Trevor W.
Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 9 p. 598 - 600
