N-三苯甲基-4,5,6,7-四氢噻吩并[3,2-c]吡啶合成路线 （共 17 条）
反应条件
triethylamine in dichloromethane T=12 - 28°C;
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
Location in patent: Page/Page column 18 ;
反应条件
triethylamine in dichloromethane; water
参考文献
EGIS GYOGYSZERGYAR NYILANOSAN MKOeD RESZVENYTARSASAG; PORCS-MAKKAY, Marta; VOLK, Balazs; GREGOR, Tamas; BARKOCZY, Jozsef; MEZEI, Tibor; BRODA, Judit; NYULASI, Balint; RUZSICS, Gyoergy; MOLNAR, Enik; DEBRECZENI, Jozsef; NAGY, Kalman; PANDUR, Angela; SZENT-KIRALLYI, Zsuzsanna
Patent: WO2011/77174 A1, 2011 ;
Location in patent: Page/Page column 28 ;
反应条件
sulfuryl dichloride; triethylamine in dichloromethane T=0°C; 1 h;
参考文献
Rogers, Erik; Araki, Hiroshi; Batory, Lindsay A.; McInnis, Christine E.; Njardarson, Jon T.
Journal of the American Chemical Society, 2007 , vol. 129, # 10 p. 2768 - 2769
反应条件
1.1: CH2Cl2 / 0 - 20 °C 2.1: Et3N / CH2Cl2 / 0 - 20 °C 2.2: 435 mg / CH2Cl2 / 17 h / 20 °C 3.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 4.1: 217 mg / KSCN; Et3N / methanol; CH2Cl2 / 15 h / 20 °C 5.1: 52 percent / Cu(tfacac)2 / benzene / 24 h / 100 °C 6.1: 66 percent / SO2Cl2; Et3N / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 10 p. 2768 - 2769
反应条件
1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 2: 217 mg / KSCN; Et3N / methanol; CH2Cl2 / 15 h / 20 °C 3: 52 percent / Cu(tfacac)2 / benzene / 24 h / 100 °C 4: 66 percent / SO2Cl2; Et3N / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 10 p. 2768 - 2769
反应条件
1: 217 mg / KSCN; Et3N / methanol; CH2Cl2 / 15 h / 20 °C 2: 52 percent / Cu(tfacac)2 / benzene / 24 h / 100 °C 3: 66 percent / SO2Cl2; Et3N / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 10 p. 2768 - 2769
反应条件
1: 52 percent / Cu(tfacac)2 / benzene / 24 h / 100 °C 2: 66 percent / SO2Cl2; Et3N / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 10 p. 2768 - 2769
反应条件
1.1: Et3N / CH2Cl2 / 0 - 20 °C 1.2: 435 mg / CH2Cl2 / 17 h / 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 3.1: 217 mg / KSCN; Et3N / methanol; CH2Cl2 / 15 h / 20 °C 4.1: 52 percent / Cu(tfacac)2 / benzene / 24 h / 100 °C 5.1: 66 percent / SO2Cl2; Et3N / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 10 p. 2768 - 2769
反应条件
1.1: 95 percent / MnO2 / CH2Cl2 / 48 h / 20 °C 2.1: CH2Cl2 / 0 - 20 °C 3.1: Et3N / CH2Cl2 / 0 - 20 °C 3.2: 435 mg / CH2Cl2 / 17 h / 20 °C 4.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C 5.1: 217 mg / KSCN; Et3N / methanol; CH2Cl2 / 15 h / 20 °C 6.1: 52 percent / Cu(tfacac)2 / benzene / 24 h / 100 °C 7.1: 66 percent / SO2Cl2; Et3N / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 10 p. 2768 - 2769
反应条件
1.1: dichloromethane / 40 - 45 °C 1.2: 20 - 70 °C 2.1: triethylamine / dichloromethane / 12 - 28 °C View Scheme
