N-三苯甲基-4,5,6,7-四氢噻吩并[3,2-c]吡啶合成路线 （共 17 条）
反应条件
hydrogenchloride in tetrahydrofuran T=20°C; 1.5 h;
参考文献
Rogers, Erik; Araki, Hiroshi; Batory, Lindsay A.; McInnis, Christine E.; Njardarson, Jon T.
Journal of the American Chemical Society, 2007 , vol. 129, # 10 p. 2768 - 2769
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane; toluene T=-5 - 10°C; 2: With boric acid trimethyl ester in tetrahydrofuran; hexane; toluene T=-5 - 10°C; 3: With water; dihydrogen peroxide in tetrahydrofuran; hexane; toluene Product distribution / selectivity;
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
Location in patent: Page/Page column 19 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane; water
参考文献
Sanofi (S.A.)
Patent: US4740510 A1, 1988 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 1.2: 1 h / 0 - 15 °C / Inert atmosphere 1.3: 2 h / 0 - 30 °C 2.1: acetone / 0.42 h / 25 - 30 °C 3.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 3.2: 7 h / 25 - 30 °C 3.3: 8 h / 0 - 25 °C 4.1: triethylamine / dichloromethane / 0.25 h / 25 - 30 °C 4.2: 6 h / 0 - 5 °C View Scheme
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 1.2: 1 h / 0 - 15 °C / Inert atmosphere 1.3: 2 h / 0 - 30 °C 2.1: acetone / 0.42 h / 25 - 30 °C 3.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 3.2: 7 h / 25 - 30 °C 3.3: 8 h / 0 - 25 °C 4.1: sodium hydrogencarbonate / water / 0.5 h / 10 - 15 °C View Scheme
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; RAMA SUBBA REDDY, Karamala; KONDAL REDDY, Bairy; VENKAT REDDY, Ghojala
Patent: WO2011/42918 A2, 2011 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 1.2: 1 h / 0 - 15 °C / Inert atmosphere 1.3: 2 h / 0 - 30 °C 2.1: hydrogenchloride; water / acetone / 3 h / 25 - 30 °C View Scheme
参考文献
Satyanarayana Reddy, Manne; Thirumalai Rajan, Srinivasan; Eswaraiah, Sajja; Rama Subba Reddy, Karamala; Kondal Reddy, Bairy; Venkat Reddy, Ghojala
Patent: US2012/202066 A1, 2012 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere
1.2: 1 h / 0 - 15 °C / Inert atmosphere
1.3: 2 h / 0 - 30 °C
2.1: acetone / 0.42 h / 25 - 30 °C
View Scheme
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
