5,6,7,7a-四氢-5-(三苯甲基)噻吩并[3,2-c]吡啶酮合成路线 （共 12 条）
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane; toluene T=-5 - 10°C; 2: With boric acid trimethyl ester in tetrahydrofuran; hexane; toluene T=-5 - 10°C; 3: With water; dihydrogen peroxide in tetrahydrofuran; hexane; toluene Product distribution / selectivity;
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
Location in patent: Page/Page column 19 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane; water
参考文献
Sanofi (S.A.)
Patent: US4740510 A1, 1988 ;
反应条件
1.1: triethylamine / dichloromethane / 9 h / 0 - 5 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 15 °C / Inert atmosphere 2.2: 1 h / 0 - 15 °C / Inert atmosphere 2.3: 2 h / 0 - 30 °C View Scheme
反应条件
1.1: triethylamine / dichloromethane / 20 °C 2.1: n-butyllithium / hexane; tetrahydrofuran / -40 - 10 °C / Inert atmosphere 2.2: -40 - 10 °C / Inert atmosphere 2.3: -40 - 20 °C / Inert atmosphere View Scheme
反应条件
1.1: triethylamine / dichloromethane / 12 - 28 °C 2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 2.2: -5 - 10 °C View Scheme
反应条件
1.1: dichloromethane / 40 - 45 °C 1.2: 20 - 70 °C 2.1: triethylamine / dichloromethane / 12 - 28 °C 3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -5 - 10 °C 3.2: -5 - 10 °C View Scheme
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice-water bath 2: hydrogenchloride / diethyl ether 3: triethylamine / dichloromethane / -15 - 20 °C View Scheme
反应条件
1.1: acetone / 0.42 h / 25 - 30 °C 2.1: potassium carbonate / acetonitrile / 0.5 h / 25 - 30 °C 2.2: 7 h / 25 - 30 °C 2.3: 8 h / 0 - 25 °C 3.1: sodium hydrogencarbonate / water / 0.5 h / 10 - 15 °C View Scheme
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; RAMA SUBBA REDDY, Karamala; KONDAL REDDY, Bairy; VENKAT REDDY, Ghojala
Patent: WO2011/42918 A2, 2011 ;
反应条件
hydrogenchloride in water; acetone T=25 - 50°C; 1 h;
参考文献
MAYUKA LABS PVT. LTD.; KRISHNAMURTHY, Chandra, Sekhar, Nakka; SINGH, Jagat; KHAN, Mohd, Yunus
Patent: WO2012/1486 A1, 2012 ;
Location in patent: Page/Page column 20 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C; 3 h; Cooling with ice-water bath;
参考文献
SYNTHON BV; THIJS, Lambertus; ZHU, Jie; OVEREEM, Arjanne
Patent: WO2011/29456 A1, 2011 ;
Location in patent: Page/Page column 15-16 ;
