N-(4-甲氧基苄基)-N-(2-吡啶基)-1,2-乙二胺合成路线 （共 6 条）
反应条件
sodium hydride in dimethyl sulfoxide 1.) below 40 deg C, 20 min, 2.) 22 deg C, 45 min;
参考文献
Blakemore, Robert C.; Ganellin, C. Robin; Garbarg, Monique; Gros, Claude; Ife, Robert J.; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 91 - 100
反应条件
1: 60 percent / pyridine / 5 h / Heating 2: 71 percent / sodium hydride / dimethylsulfoxide / 1.) below 40 deg C, 20 min, 2.) 22 deg C, 45 min View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 91 - 100
反应条件
1: 91 percent / acetic anhydride / diethyl ether / 16 h / 22 °C 2: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 3: 79 percent / potassium carbonate / dimethylformamide / 2 h / 100 °C 4: 86 percent / LiAlH4 / diethyl ether / 18 h / 22 °C View Scheme
参考文献
Blakemore, Robert C.; Ganellin, C. Robin; Garbarg, Monique; Gros, Claude; Ife, Robert J.; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 91 - 100
反应条件
1: 91 percent / acetic anhydride / diethyl ether / 16 h / 22 °C 2: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 3: 79 percent / potassium carbonate / dimethylformamide / 2 h / 100 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 91 - 100
反应条件
1: 91 percent / acetic anhydride / diethyl ether / 16 h / 22 °C 2: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Blakemore, Robert C.; Ganellin, C. Robin; Garbarg, Monique; Gros, Claude; Ife, Robert J.; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 91 - 100
反应条件
acetic anhydride in diethyl ether
T=22°C; 16 h;
参考文献
Blakemore, Robert C.; Ganellin, C. Robin; Garbarg, Monique; Gros, Claude; Ife, Robert J.; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 91 - 100
