N’-(4-氰基丁基)-N-(4-甲氧基苄基)-N’-甲基-N-2-吡啶基-1,2-乙二胺合成路线 （共 6 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=100°C; 2 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 91 - 100
反应条件
1: 60 percent / pyridine / 5 h / Heating 2: 71 percent / sodium hydride / dimethylsulfoxide / 1.) below 40 deg C, 20 min, 2.) 22 deg C, 45 min 3: 91 percent / acetic anhydride / diethyl ether / 16 h / 22 °C 4: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 5: 79 percent / potassium carbonate / dimethylformamide / 2 h / 100 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 91 - 100
反应条件
1: 71 percent / sodium hydride / dimethylsulfoxide / 1.) below 40 deg C, 20 min, 2.) 22 deg C, 45 min 2: 91 percent / acetic anhydride / diethyl ether / 16 h / 22 °C 3: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 4: 79 percent / potassium carbonate / dimethylformamide / 2 h / 100 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 91 - 100
反应条件
1: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 2: 79 percent / potassium carbonate / dimethylformamide / 2 h / 100 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 91 - 100
反应条件
1: 91 percent / acetic anhydride / diethyl ether / 16 h / 22 °C 2: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating 3: 79 percent / potassium carbonate / dimethylformamide / 2 h / 100 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 22, p. 91 - 100
反应条件
lithium aluminium tetrahydride in diethyl ether T=22°C; 18 h;
参考文献
Blakemore, Robert C.; Ganellin, C. Robin; Garbarg, Monique; Gros, Claude; Ife, Robert J.; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 91 - 100
