((S)-1-((r)-1-苯基乙基)吡咯烷-3-基)甲醇合成路线 （共 11 条）
反应条件
lithium aluminium tetrahydride in diethyl ether 3.5 h; Heating;
参考文献
Nielsen, Lone; Brehm, Lotte; Krogsgaard-Larsen, Povl
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 71 - 77
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Reduction; 7 h; reflux;
参考文献
Fava, Cristiana; Galeazzi, Roberta; Mobbili, Giovanna; Orena, Mario
Heterocycles, 1999 , vol. 51, # 10 p. 2463 - 2470
反应条件
1: 16 percent / p-TsOH / 24 h / Heating 2: 51 percent / LiAlH / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 10 p. 1711 - 1715
反应条件
1: 25 percent / 4A sieves / toluene / Ambient temperature 2: 51 percent / LiAlH / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 10 p. 1711 - 1715
反应条件
1: 97 percent / 4 h / 160 °C 2: acetyl chloride / 16 h / Heating 3: 85 percent / lithium aluminum hydride / diethyl ether / 3.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 1 p. 71 - 77
反应条件
1: 25 percent / 4A sieves / toluene / Ambient temperature 2: 51 percent / LiAlH / tetrahydrofuran / 24 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 10 p. 1711 - 1715
反应条件
1: 97 percent / 4 h / 160 °C 2: acetyl chloride / 16 h / Heating 3: 85 percent / lithium aluminum hydride / diethyl ether / 3.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 1 p. 71 - 77
反应条件
1: 76 percent / NaBH4 / ethanol / 3 h / 0 °C 2: 85 percent / LiAlH4 / tetrahydrofuran / 7 h / reflux View Scheme
参考文献
Heterocycles, , vol. 51, # 10 p. 2463 - 2470
反应条件
hydrogen; palladium dihydroxide in methanol; water
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 22 p. 3497 - 3500
反应条件
1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C 2.1: 1-chloroethyl chlorocarbonate / 1,2-dichloro-ethane / 5 h / Reflux 2.2: 3 h / Reflux 2.3: 3 h / 0 °C View Scheme
参考文献
WO2011/19090 A1, ;
WO 2011/019090 A1
