((S)-1-((r)-1-苯基乙基)吡咯烷-3-基)甲醇合成路线 （共 11 条）
反应条件
1: 92 percent / thionyl chloride / CHCl3 / 2 h / Heating
2: 67 percent / tricaprylmethylammonium chloride / H2O / 48 h / 100 °C
3: 1.) acetyl chloride, 2.) water / 1.) RT, 48 h, 2.) 1 h
4: 62 percent / H2 / 10percent Pd-C / methanol / 2205.2 Torr
View Scheme
参考文献
Nielsen, Lone; Brehm, Lotte; Krogsgaard-Larsen, Povl
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 71 - 77
