反应条件
1: 1) n-BuLi / 1) THF, hexane, -60 deg C, 1h, 2) HMPA, RT, 36h
2: 3N HCl / methanol / 0.33 h / Ambient temperature
3: 41 percent / t-BuOOH, Ti(O-i-Pr)4, L-(+)-DIPT, molecular sieves 4 Angstroem / CH2Cl2 / 4 h / -21 °C
5: 97 percent / imidazole / dimethylformamide
6: 1) disiamylborane, 2) 2N LiOH / 2) Pd(PPh3)4 / 1) THF, 0 deg C, 1h
7: 55 percent / n-Bu4NF / tetrahydrofuran / 12 h / Ambient temperature
View Scheme
参考文献
Kobayashi, Yuichi; Shimazaki, Toshiyuki; Taguchi, Hideki; Sato, Fumie
Journal of Organic Chemistry, 1990 , vol. 55, # 19 p. 5324 - 5335
