反应条件
1: 1.) BuLi / 1.) THF, HMPT, hexane, 1 h, 2.) THF, HMPT, hexane, overnight
2: 77 percent / PBr3, pyridine / diethyl ether / 1.) -15 deg C, 2 h, 2.) room temp., 3 h, then 30 deg C, 45 min
3: 1.) Mg / 1.) Et2O, 2.) Et2O, -15 deg C, 0.5 h, -15 to 0 deg C, 0.5 h
4: 68 percent / propionic acid / 2 h / 136 - 139 °C
5: 90 percent / NaB4, aq. NaOH, Ni(OAr)2*4H2O, ethylenediamine, H2 / ethanol / Ambient temperature
View Scheme
参考文献
Odinokov; Vakhidov; Shakhmaev; Zorin
Chemistry of Natural Compounds, 1997 , vol. 33, # 3 p. 350 - 352
