1: K2CO3 / 1 h / Ambient temperature
2: acetonitrile / 0.08 h / Ambient temperature
3: 2 N NaOMe / methanol / 0.33 h / Heating; further reagent: KCN
View Scheme
1: dimethyl lt;1-(methoxycarbonyl)ethylgt;phosphonate With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 40°C; Horner-Wadsworth-Emmons olefination;
2: pentanal in tetrahydrofuran; mineral oil
Horner-Wadsworth-Emmons olefination; 24 h; Reflux; optical yield given as percent de;
参考文献
Nawrath, Thorben; Gerth, Klaus; Mueller, Rolf; Schulz, Stefan
Chemistry and Biodiversity, 2010 , vol. 7, # 9 p. 2228 - 2253