N,N'-二甲基乙二胺合成路线 （共 190 条）
反应条件
in water 24 h; Ambient temperature;
参考文献
Rouzic, Arlette Le; Raphalen, Desire; Papillon, Denise; Kerfanto, Michel
Tetrahedron Letters, 1985 , vol. 26, # 15 p. 1853 - 1856
参考文献
Ulrich,H. et al.
Journal of Organic Chemistry, 1967 , vol. 32, p. 1360 - 1362
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
Klinge Pharma GmbH
Patent: EP1042291 B1, 2005 ;
Location in patent: Page/Page column 43 ;
反应条件
potassium carbonate in butanone T=100°C; 24 h;
参考文献
Corsano; Strappaghetti; Brasili
Archiv der Pharmazie, 1988 , vol. 321, # 3 p. 171 - 174
反应条件
in benzene 12 h; Heating;
参考文献
Tetrahedron, , vol. 41, # 18 p. 3803 - 3812
反应条件
in water 18 h; Ambient temperature;
参考文献
Dale, Johannes; Sigvartsen, Turid
Acta Chemica Scandinavica, 1991 , vol. 45, # 10 p. 1064 - 1070
反应条件
in toluene T=0°C; 3 h; Heating / reflux;
参考文献
METABASIS THERAPEUTICS, INC.
Patent: WO2009/23718 A2, 2009 ;
Location in patent: Page/Page column 143-145 ;
WO 2009/023718 A2
反应条件
transamination, boiling the educts in inert atmosphere, distn. of dimethylamine during reaction; distn.;
参考文献
Niedenzu, K.; Beyer, H.; Dawson, J. W.
Inorganic Chemistry, 1962 , vol. 1, p. 738 - 742
反应条件
transamination, boiling the educts in inert atmosphere, distn. of the dimethylamine during the reaction; distn.;
参考文献
Gmelin Handbook: B: B-Verb.1, 2.5.1.3, page 122 - 126
反应条件
in diethyl ether Heating;
参考文献
Daub, Joerg; Hasenhuendl, Adelheid; Krenkler, Karl P.; Schmetzer, Johannes
Liebigs Annalen der Chemie, 1980 , # 7 p. 997 - 1015
