1.1: tetrabutyl ammonium fluoride / tetrahydrofuran; ethanol / 1.5 h / 0 °C / Inert atmosphere 2.1: copper(l) iodide; tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 8.5 h / 20 °C / Inert atmosphere 3.1: hydrogen; palladium / methanol / 96 h / 20 °C 4.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 16 h / -20 - 20 °C / Inert atmosphere 5.1: toluene-4-sulfonic acid / methanol / 48 h / 20 °C / Inert atmosphere 5.2: 20 °C / Inert atmosphere 6.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 7.1: sodium chlorite; sodium dihydrogen phosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C / Inert atmosphere 8.1: nitromethane / 99.5 h / 50 - 65 °C / Inert atmosphere 9.1: palladium 10 on activated carbon; hydrogen / methanol / 24 h / 20 °C 10.1: trifluoroacetic acid / water / 2 h / 20 °C View Scheme

1.1: copper(l) iodide; tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 8.5 h / 20 °C / Inert atmosphere 2.1: hydrogen; palladium / methanol / 96 h / 20 °C 3.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 16 h / -20 - 20 °C / Inert atmosphere 4.1: toluene-4-sulfonic acid / methanol / 48 h / 20 °C / Inert atmosphere 4.2: 20 °C / Inert atmosphere 5.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 6.1: sodium chlorite; sodium dihydrogen phosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C / Inert atmosphere 7.1: nitromethane / 99.5 h / 50 - 65 °C / Inert atmosphere 8.1: palladium 10 on activated carbon; hydrogen / methanol / 24 h / 20 °C 9.1: trifluoroacetic acid / water / 2 h / 20 °C View Scheme

1.1: copper(l) iodide; tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 8.5 h / 20 °C / Inert atmosphere 2.1: hydrogen; palladium / methanol / 96 h / 20 °C 3.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 16 h / -20 - 20 °C / Inert atmosphere 4.1: toluene-4-sulfonic acid / methanol / 48 h / 20 °C / Inert atmosphere 4.2: 20 °C / Inert atmosphere 5.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 6.1: sodium chlorite; sodium dihydrogen phosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C / Inert atmosphere 7.1: nitromethane / 99.5 h / 50 - 65 °C / Inert atmosphere 8.1: palladium 10 on activated carbon; hydrogen / methanol / 24 h / 20 °C 9.1: trifluoroacetic acid / water / 2 h / 20 °C View Scheme

1.1: hydrogen; palladium / methanol / 96 h / 20 °C 2.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 16 h / -20 - 20 °C / Inert atmosphere 3.1: toluene-4-sulfonic acid / methanol / 48 h / 20 °C / Inert atmosphere 3.2: 20 °C / Inert atmosphere 4.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 5.1: sodium chlorite; sodium dihydrogen phosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C / Inert atmosphere 6.1: nitromethane / 99.5 h / 50 - 65 °C / Inert atmosphere 7.1: palladium 10 on activated carbon; hydrogen / methanol / 24 h / 20 °C 8.1: trifluoroacetic acid / water / 2 h / 20 °C View Scheme

1: palladium 10 on activated carbon; hydrogen / methanol / 24 h / 20 °C 2: trifluoroacetic acid / water / 2 h / 20 °C View Scheme

1.1: sodium acetate; sodium hydroxide / water / Reflux; Inert atmosphere 1.2: Inert atmosphere; Reflux 2.1: phosphorus tribromide / ethyl acetate / 4.5 h / 145 °C / Inert atmosphere 3.1: hydrogenchloride / tetrahydrofuran; diethyl ether; water / 0.08 h / 20 °C / Inert atmosphere 3.2: 24 h / Inert atmosphere; Reflux 4.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 h / 45 °C / Inert atmosphere 5.1: copper(l) iodide; tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 8.5 h / 20 °C / Inert atmosphere 6.1: hydrogen; palladium / methanol / 96 h / 20 °C 7.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 16 h / -20 - 20 °C / Inert atmosphere 8.1: toluene-4-sulfonic acid / methanol / 48 h / 20 °C / Inert atmosphere 8.2: 20 °C / Inert atmosphere 9.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 10.1: sodium chlorite; sodium dihydrogen phosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C / Inert atmosphere 11.1: nitromethane / 99.5 h / 50 - 65 °C / Inert atmosphere 12.1: palladium 10 on activated carbon; hydrogen / methanol / 24 h / 20 °C 13.1: trifluoroacetic acid / water / 2 h / 20 °C View Scheme

1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 h / 45 °C / Inert atmosphere 2.1: copper(l) iodide; tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 8.5 h / 20 °C / Inert atmosphere 3.1: hydrogen; palladium / methanol / 96 h / 20 °C 4.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 16 h / -20 - 20 °C / Inert atmosphere 5.1: toluene-4-sulfonic acid / methanol / 48 h / 20 °C / Inert atmosphere 5.2: 20 °C / Inert atmosphere 6.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 7.1: sodium chlorite; sodium dihydrogen phosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C / Inert atmosphere 8.1: nitromethane / 99.5 h / 50 - 65 °C / Inert atmosphere 9.1: palladium 10 on activated carbon; hydrogen / methanol / 24 h / 20 °C 10.1: trifluoroacetic acid / water / 2 h / 20 °C View Scheme

1.1: phosphorus tribromide / ethyl acetate / 4.5 h / 145 °C / Inert atmosphere 2.1: hydrogenchloride / tetrahydrofuran; diethyl ether; water / 0.08 h / 20 °C / Inert atmosphere 2.2: 24 h / Inert atmosphere; Reflux 3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 h / 45 °C / Inert atmosphere 4.1: copper(l) iodide; tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 8.5 h / 20 °C / Inert atmosphere 5.1: hydrogen; palladium / methanol / 96 h / 20 °C 6.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 16 h / -20 - 20 °C / Inert atmosphere 7.1: toluene-4-sulfonic acid / methanol / 48 h / 20 °C / Inert atmosphere 7.2: 20 °C / Inert atmosphere 8.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 9.1: sodium chlorite; sodium dihydrogen phosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C / Inert atmosphere 10.1: nitromethane / 99.5 h / 50 - 65 °C / Inert atmosphere 11.1: palladium 10 on activated carbon; hydrogen / methanol / 24 h / 20 °C 12.1: trifluoroacetic acid / water / 2 h / 20 °C View Scheme

1.1: hydrogenchloride / tetrahydrofuran; diethyl ether; water / 0.08 h / 20 °C / Inert atmosphere 1.2: 24 h / Inert atmosphere; Reflux 2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 30 h / 45 °C / Inert atmosphere 3.1: copper(l) iodide; tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 8.5 h / 20 °C / Inert atmosphere 4.1: hydrogen; palladium / methanol / 96 h / 20 °C 5.1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 16 h / -20 - 20 °C / Inert atmosphere 6.1: toluene-4-sulfonic acid / methanol / 48 h / 20 °C / Inert atmosphere 6.2: 20 °C / Inert atmosphere 7.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 8.1: sodium chlorite; sodium dihydrogen phosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C / Inert atmosphere 9.1: nitromethane / 99.5 h / 50 - 65 °C / Inert atmosphere 10.1: palladium 10 on activated carbon; hydrogen / methanol / 24 h / 20 °C 11.1: trifluoroacetic acid / water / 2 h / 20 °C View Scheme

1.1: toluene-4-sulfonic acid / methanol / 48 h / 20 °C / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 3.1: sodium chlorite; sodium dihydrogen phosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 20 °C / Inert atmosphere 4.1: nitromethane / 99.5 h / 50 - 65 °C / Inert atmosphere 5.1: palladium 10 on activated carbon; hydrogen / methanol / 24 h / 20 °C 6.1: trifluoroacetic acid / water / 2 h / 20 °C View Scheme