5-溴-2,2'-联噻吩-5'-甲醛合成路线 （共 14 条）
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether T=80°C; Suzuki cross-coupling; 20 h;
参考文献
Costa, Susana P.G.; Batista, Rosa M.F.; Raposo, M. Manuela M.
Tetrahedron, 2008 , vol. 64, # 41 p. 9733 - 9737
反应条件
1: sodium tetrahydroborate / methanol; dichloromethane / 0.5 h / |Cooling with ice 2: 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; potassium carbonate; palladium diacetate / acetonitrile; water / 24 h / 20 °C / |Inert atmosphere 3: tetrabutylammomium bromide; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; Oxonereg; / dichloromethane; acetone / 20 °C View Scheme
参考文献
Lin, Jinshun; Jin, Xiuli; Bu, Yiwen; Cao, Deliang; Zhang, Nannan; Li, Shangfu; Sun, Qinsheng; Tan, Chunyan; Gao, Chunmei; Jiang, Yuyang
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 48 p. 9734 - 9746
反应条件
sodium chlorite; dihydrogen peroxide in acetonitrile T=10°C; 1 h;
参考文献
Kawano, Shin-Ichiro; Fujita, Norifumi; Shinkai, Seiji
Chemistry - A European Journal, 2005 , vol. 11, # 16 p. 4735 - 4742
反应条件
1: benzyltriethylammonium chloride, CuI / Pd<P(Ph)3>4 / benzene / 0 °C 2: 1.) Zn, PPh3, 3.) BuLi / 1) CH2Cl2, room temperature, 48 h; 2) 2 h; 3) THF, -78 deg C, 1 h, 25 deg C, 1 h View Scheme
参考文献
D'Auria, M.; Mico, A. De; D'Onofrio, F.; Piancatelli, G.
Journal of Organic Chemistry, 1987 , vol. 52, # 23 p. 5243 - 5247
