in acetonitrile Heating; Yield given;

in acetonitrile 3 h; Heating;

1: 74.5 percent / NaH / acetonitrile 2: 76.5 percent / NH3 / methanol / 48 h / Ambient temperature 3: 97 percent / pyridine / 4 h / Ambient temperature 4: 56 percent / KF, N,O-bis(trimethylsilyl)acetamide / 18-crown-6 ether / acetonitrile / 12 h / Heating 5: 82 percent / NH3 / methanol / 12 h / Ambient temperature View Scheme

1: With ammonium hydroxide in water 2: With acetic acid in water T=-5°C; 8 h;

1: 74.5 percent / NaH / acetonitrile 2: 76.5 percent / NH3 / methanol / 48 h / Ambient temperature 3: 97 percent / pyridine / 4 h / Ambient temperature 4: 56 percent / KF, N,O-bis(trimethylsilyl)acetamide / 18-crown-6 ether / acetonitrile / 12 h / Heating 5: 82 percent / NH3 / methanol / 12 h / Ambient temperature 6: 75 percent / NH4OH, H2O2 / dioxane; methanol; H2O / 12 h / Ambient temperature View Scheme