N-(8-氧代-5,6,7,8-四氢萘-1-基)乙酰胺合成路线 （共 9 条）
反应条件
potassium permanganate; magnesium sulfate in water; acetone T=20°C; 2.25 h;
参考文献
ALLERGAN, INC.
Patent: WO2003/99795 A1, 2003 ;
Location in patent: Page 74, 75 ;
WO 03/099795 A1
反应条件
triethylamine in potassium permanganate; dichloromethane; chloroform; acetone
参考文献
Heidelbaugh, Todd M.; Chow, Ken; Nguyen, Phong; Gil, Daniel; Donello, John E.
Patent: US2005/75366 A1, 2005 ;
US 20050075366 A1
反应条件
1: pyridine / 20 °C 2: KMnO4; aq. MgSO4 / acetone View Scheme
参考文献
Mukhina, Olga A.; Bhuvan Kumar; Arisco, Teresa M.; Valiulin, Roman A.; Metzel, Greg A.; Kutateladze, Andrei G.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 40 p. 9423 - 9428
反应条件
1: tin (II)-chloride; iron (II)-sulfate; aqueous methanol. hydrochloric acid View Scheme
参考文献
Nakamura
Yakugaku Zasshi, 1942 , vol. 62, p. 236,238; dtsch. Ref. S. 57
Chem.Abstr., 1950 , p. 9869
参考文献
Nakamura
Yakugaku Zasshi, 1942 , vol. 62, p. 236,238; dtsch. Ref. S. 57
Chem.Abstr., 1950 , p. 9869
反应条件
1.1: 9.11 g / aq. HCl / 3 h / 90 °C 2.1: HBr; NaNO2 / ethanol; H2O / 0.25 h / 0 °C 2.2: 70 percent / CuBr; HBr / ethanol; H2O / 0.25 h / 95 °C View Scheme
参考文献
Nguyen, Phong; Corpuz, Evelyn; Heidelbaugh, Todd M.; Chow, Ken; Garst, Michael E.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10195 - 10198
反应条件
1: aq. NaOH / ethanol / Heating 2: NaNO2; Cu(I)Cl; aq. HCl / 2 h / Heating View Scheme
参考文献
Nguyen, Phong; Corpuz, Evelyn; Heidelbaugh, Todd M.; Chow, Ken; Garst, Michael E.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10195 - 10198
反应条件
1: aq. NaOH / ethanol / Heating 2: NOBF4 / 1,2-dichloro-benzene / 2 h / Heating View Scheme
参考文献
Nguyen, Phong; Corpuz, Evelyn; Heidelbaugh, Todd M.; Chow, Ken; Garst, Michael E.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10195 - 10198
反应条件
hydrogenchloride in water T=90°C; 3 h;
参考文献
WO2003/99795 A1, ;
Page 74, 75 ;
WO 03/099795 A1
