2'-beta-氟-2',3'-二脱氧腺苷合成路线 （共 55 条）
反应条件
1: 4-dimethylaminopyridine; pyridine / CH2Cl2 / 2 h / 0 °C
2: tBuOK / dimethylsulfoxide / 0.5 h
3: H2 / Pd/C / tetrahydrofuran / 55 h / 20 °C / 3620.13 Torr
4: DOWEX 50 W pyridinium form / methanol; ethanol / 2 h
View Scheme
参考文献
Woltermann, Christopher J.; Lapin, Yuri A.; Kunnen, Kevin B.; Tueting, David R.; Sanchez, Ignacio H.
Tetrahedron, 2004 , vol. 60, # 15 p. 3445 - 3449
反应条件
1: cyclohexene / Pd(OH)2/C / ethanol / 18 h / Heating
2: 4-dimethylaminopyridine; pyridine / CH2Cl2 / 2 h / 0 °C
3: tBuOK / dimethylsulfoxide / 0.5 h
4: H2 / Pd/C / tetrahydrofuran / 55 h / 20 °C / 3620.13 Torr
5: DOWEX 50 W pyridinium form / methanol; ethanol / 2 h
View Scheme
参考文献
Woltermann, Christopher J.; Lapin, Yuri A.; Kunnen, Kevin B.; Tueting, David R.; Sanchez, Ignacio H.
Tetrahedron, 2004 , vol. 60, # 15 p. 3445 - 3449
反应条件
1: pyridine, triethylamine
2: pyridine, triethylamine
3: 55 percent / 1N aq. NaOH / ethanol / Heating
4: 56 percent / hydrogen / Pd/C / ethanol
View Scheme
参考文献
Siddiqui, Maqbool A.; Driscoll, John S.; Marquez, Victor E.
Tetrahedron Letters, 1998 , vol. 39, # 13 p. 1657 - 1660
反应条件
1: pyridine, triethylamine
2: 55 percent / 1N aq. NaOH / ethanol / Heating
3: 56 percent / hydrogen / Pd/C / ethanol
View Scheme
参考文献
Siddiqui, Maqbool A.; Driscoll, John S.; Marquez, Victor E.
Tetrahedron Letters, 1998 , vol. 39, # 13 p. 1657 - 1660
反应条件
1: pyridine, triethylamine
2: 2 percent / aq. NaOH / ethanol / Heating
3: 56 percent / hydrogen / Pd/C / ethanol
View Scheme
参考文献
Siddiqui, Maqbool A.; Driscoll, John S.; Marquez, Victor E.
Tetrahedron Letters, 1998 , vol. 39, # 13 p. 1657 - 1660
反应条件
1: 2 percent / aq. NaOH / ethanol / Heating
2: 56 percent / hydrogen / Pd/C / ethanol
View Scheme
参考文献
Siddiqui, Maqbool A.; Driscoll, John S.; Marquez, Victor E.
Tetrahedron Letters, 1998 , vol. 39, # 13 p. 1657 - 1660
反应条件
1: 55 percent / 1N aq. NaOH / ethanol / Heating
2: 56 percent / hydrogen / Pd/C / ethanol
View Scheme
参考文献
Siddiqui, Maqbool A.; Driscoll, John S.; Marquez, Victor E.
Tetrahedron Letters, 1998 , vol. 39, # 13 p. 1657 - 1660
反应条件
1: pyridine, triethylamine
2: pyridine, triethylamine
3: 2 percent / aq. NaOH / ethanol / Heating
4: 56 percent / hydrogen / Pd/C / ethanol
View Scheme
参考文献
Siddiqui, Maqbool A.; Driscoll, John S.; Marquez, Victor E.
Tetrahedron Letters, 1998 , vol. 39, # 13 p. 1657 - 1660
反应条件
1: 81 percent / Ph2SiH2; AIBN / dioxane
2: 88 percent / HCl
View Scheme
参考文献
Izawa, Kunisuke; Takamatsu, Satoshi; Katayama, Satoshi; Hirose, Naoko; Kozai, Shigetaka; Maruyama, Tokumi
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 5-8 p. 507 - 517
反应条件
1: 4A molecular sieves / CH2Cl2 / 15 h / Heating
2: 90 percent / NH3 / methanol / 84 h / 95 - 100 °C
3: 85 percent / imidazole / dimethylformamide / Ambient temperature
4: 0.029 g / (dimethylamido)pyridine / dimethylformamide; acetonitrile / 1.5 h / Ambient temperature
5: 71 percent / 2,2'-azobis(2-methylpropionitrile), tributyltin hydride / toluene / 0.5 h / Heating
6: 78 percent / 1 M tetrabutylammonium fluoride / tetrahydrofuran / 0.18 h / Ambient temperature
View Scheme
参考文献
Marquez; Tseng; Mitsuya; Aoki; Kelley; Ford Jr.; Roth; Broder; Johns; Driscoll
Journal of Medicinal Chemistry, 1990 , vol. 33, # 3 p. 978 - 985
