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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
110143-65-2
合成路线
（共 7 条）
110143-65-2
→
反应条件
90315-82-5
(R)-2-羟基-4-苯基丁酸乙酯
反应条件
1: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr 2: 86 percent / KOH / ethanol / 16 h / Ambient temperature 3: 98 percent / conc. H2SO4 / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
110143-65-2
→
反应条件
88767-98-0
(R)-1-(乙氧羰基)-3-苯基丙基三氟甲磺酸酯
反应条件
1: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr 2: 86 percent / KOH / ethanol / 16 h / Ambient temperature 3: 98 percent / conc. H2SO4 / 16 h / Ambient temperature 4: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
110143-65-2
→
反应条件
29678-81-7
(R)-2-羟基-4-苯基丁酸
反应条件
1: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr 2: 86 percent / KOH / ethanol / 16 h / Ambient temperature View Scheme
参考文献
Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991
110143-65-2
→
反应条件
110221-44-8
盐酸替莫普利
反应条件
1: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr 2: 86 percent / KOH / ethanol / 16 h / Ambient temperature 3: 98 percent / conc. H2SO4 / 16 h / Ambient temperature 4: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 5: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 6: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature 7: 78 percent / 4 N aq. HCl / dioxane / 16 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 11 p. 1984 - 1991
110143-65-2
→
反应条件
110143-57-2
(2S,6R)-6-[[(1S)-1-乙氧羰基]-3-苯基丙基]氨基-2-(2-噻吩基)-1,4-硫氮杂卓-5-酮
反应条件
1: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr 2: 86 percent / KOH / ethanol / 16 h / Ambient temperature 3: 98 percent / conc. H2SO4 / 16 h / Ambient temperature 4: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 5: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991
110143-65-2
→
反应条件
110221-53-9
替莫普利
反应条件
1: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr 2: 86 percent / KOH / ethanol / 16 h / Ambient temperature 3: 98 percent / conc. H2SO4 / 16 h / Ambient temperature 4: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 5: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 6: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature 7: 78 percent / 4 N aq. HCl / dioxane / 16 h / Ambient temperature 8: 96 percent / 1 N aq. NaOH / 16 h / Ambient temperature View Scheme
参考文献
Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991
110143-65-2
→
反应条件
110221-37-9
反应条件
Multi-step reaction with 6 steps 1: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr2: 86 percent / KOH / ethanol / 16 h / Ambient temperature3: 98 percent / conc. H2SO4 / 16 h / Ambient temperature4: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C5: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature6: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature
参考文献
Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991
