(3R)-3-甲基-4-[(四氢-2H-吡喃-2-基)氧基]-丁腈合成路线 （共 8 条）
反应条件
in dimethyl sulfoxide T=70°C; 6 h;
参考文献
Journal of Organic Chemistry, , vol. 57, # 22 p. 5851 - 5856
反应条件
in methanol; N,N,N',N',N'',N''-hexamethylphosphoric triamide; N,N-dimethyl-formamide T=80°C; 12 h;
参考文献
Tetrahedron Letters, , vol. 38, # 22 p. 3801 - 3804
Steroids, , vol. 65, # 7 p. 401 - 407
反应条件
1: 95 percent / DMAP; pyridine / 4 h / 20 °C 2: 81 percent / methanol; dimethylformamide; hexamethylphosphoric acid triamide / 12 h / 80 °C View Scheme
参考文献
Steroids, , vol. 65, # 7 p. 401 - 407
反应条件
1: LiAlH4 / tetrahydrofuran / 1.5 h / Heating 2: 95 percent / DMAP; pyridine / 4 h / 20 °C 3: 81 percent / methanol; dimethylformamide; hexamethylphosphoric acid triamide / 12 h / 80 °C View Scheme
参考文献
Steroids, , vol. 65, # 7 p. 401 - 407
反应条件
in dimethyl sulfoxide 48 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 23 p. 3533 - 3541
反应条件
1: CSA / CH2Cl2 2: LiAlH4 / tetrahydrofuran 3: 95 percent / pyridine, DMAP 4: 81 percent / methanol; dimethylformamide; hexamethylphosphoric acid triamide / 12 h / 80 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 22 p. 3801 - 3804
反应条件
lithium aluminium tetrahydride in diethyl ether T=20°C; Reduction; 1 h;
参考文献
Natsugari, Hideaki; Ikeura, Yoshinori; Kamo, Izumi; Ishimaru, Takenori; Ishichi, Yuji; Fujishima, Akira; Tanaka, Toshimasa; Kasahara, Fumiko; Kawada, Mitsuru; Doi, Takayuki
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3982 - 3993
反应条件
diisobutylaluminium hydride in toluene T=-70°C;
参考文献
D'Ambra, Thomas E.; Javitt, Norman B.; Lacy, James; Srinivasan, Puliyur; Warchol, Tadeusz
Steroids, 2000 , vol. 65, # 7 p. 401 - 407
