四氢-2H-吡喃-4-羧酸甲酯合成路线 （共 26 条）
反应条件
potassium carbonate in acetone 3 h; Heating / reflux;
参考文献
Bayer Pharmaceuticals Corporation
Patent: US2004/224997 A1, 2004 ;
Location in patent: Page 18 ;
反应条件
thionyl chloride T=20°C; 3 h;
参考文献
WO2013/66729 A1, ;
Page/Page column 184; 185 ;
WO 2013/066729 A1
反应条件
1: thionyl chloride View Scheme
参考文献
Journal of the Chemical Society, , p. 2525,2529
参考文献
Journal of the Chemical Society, , p. 2525,2529
反应条件
hydrazine in methanol T=120°C; 0.333333 h; Irradiation;
参考文献
Bolin, David Robert; Michoud, Christophe
Patent: US2006/178532 A1, 2006 ;
Location in patent: Page/Page column 7; 8 ;
US 20060178532 A1
反应条件
ammonia in water T=20°C; 18 h;
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; Pulici, Maurizio; Traquandi, Gabriella; Marchionni, Chiara; Scolaro, Alessandra; Colombo, Nicoletta
Patent: US2013/324551 A1, 2013 ;
Location in patent: Paragraph 0326; 0327 ;
反应条件
diisobutylaluminium hydride in hexanes; diethyl ether T=-78°C; 1.66667 h;
参考文献
H. LUNDBECK A/S; ESKILDSEN, Jørgen
Patent: WO2014/49133 A1, 2014 ;
Location in patent: Page/Page column 49-50 ;
