1-[2-[二[4-(三氟甲基)苯基]甲氧基]乙基]-5,6-二氢-2H-吡啶-3-羧酸合成路线 （共 4 条）
反应条件
lithium hydroxide in methanol 64 h; Ambient temperature;
参考文献
Pavia, Michael R.; Lobbestael, Sandra J.; Nugiel, David; Mayhugh, Daniel R.; Gregor, Vlad E.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4238 - 4248
反应条件
1: 1.) Mg / 1.) Et2O, 2.) Et2O, a) reflux, 1.5 h, b) RT, 16 h 2: 72.6 percent / conc. H2SO4 / toluene / 2 h / 85 - 90 °C 3: 97.2 g / K2CO3 / acetonitrile / 15 h / Heating 4: 2 N aq. LiOH / methanol / 64 h / Ambient temperature View Scheme
参考文献
Pavia, Michael R.; Lobbestael, Sandra J.; Nugiel, David; Mayhugh, Daniel R.; Gregor, Vlad E.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4238 - 4248
反应条件
1: 1.) Mg / 1.) Et2O, 2.) Et2O, a) reflux, 1.5 h, b) RT, 16 h 2: 72.6 percent / conc. H2SO4 / toluene / 2 h / 85 - 90 °C 3: 97.2 g / K2CO3 / acetonitrile / 15 h / Heating 4: 2 N aq. LiOH / methanol / 64 h / Ambient temperature View Scheme
参考文献
Pavia, Michael R.; Lobbestael, Sandra J.; Nugiel, David; Mayhugh, Daniel R.; Gregor, Vlad E.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4238 - 4248
反应条件
1: 72.6 percent / conc. H2SO4 / toluene / 2 h / 85 - 90 °C 2: 97.2 g / K2CO3 / acetonitrile / 15 h / Heating 3: 2 N aq. LiOH / methanol / 64 h / Ambient temperature View Scheme
参考文献
Pavia, Michael R.; Lobbestael, Sandra J.; Nugiel, David; Mayhugh, Daniel R.; Gregor, Vlad E.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4238 - 4248
