4-氨基-3,5-二氟苯甲腈合成路线 （共 8 条）
反应条件
in 1-methyl-pyrrolidin-2-one Rosenmund-van Braun Cyanation; 1.5 h; Reflux;
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
反应条件
in N,N-dimethyl-formamide 2 h; Heating / reflux;
参考文献
AMOREPACIFIC CORPORATION
Patent: WO2006/98554 A1, 2006 ;
Location in patent: Page/Page column 78 ;
WO 2006/098554 A1
反应条件
1: With diisobutylaluminium hydride in toluene T=0 - 20°C; 2 h; 2: With water; citric acid in toluene
参考文献
CHROMA THERAPEUTICS LTD.
Patent: WO2007/129040 A1, 2007 ;
Location in patent: Page/Page column 35 ;
WO 2007/129040 A1
反应条件
1: With sulfuric acid; acetic acid; sodium nitrite T=20°C; 1 h; 2: With hydrogen bromide; copper(I) bromide in water T=20°C; Sandmeyer Reaction; 13.5 h;
参考文献
Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5235 - 5246
反应条件
sodium nitrite; copper(I) bromide in hydrogen bromide; acetic acid
参考文献
Seiko Epson Corporation
Patent: US5354502 A1, 1994 ;
反应条件
sulfuric acid; sodium nitrite in methanol; hydrogen bromide; acetic acid; acetone
参考文献
Seiko Epson Corporation
Patent: US4883609 A1, 1989 ;
反应条件
sodium hydroxide
14 h; Reflux;
参考文献
Bleger, David; Schwarz, Jutta; Brouwer, Albert M.; Hecht, Stefan
Journal of the American Chemical Society, 2012 , vol. 134, # 51 p. 20597 - 20600
