7-乙基-10-羟基喜树碱中间体合成路线 （共 47 条）
反应条件
1: NaNO2, HOAc / acetic anhydride / 4 h / 0 °C 2: CCl4 / 5 h / Heating 3: 1) LiOH*H2O, 2) aqueous HOAc / 1) EtOH, water, room temperature, 1 h, 2) CH2Cl2, room temperature, 24 h 4: 79 percent / 80percent aqueous trifluoroacetic acid / 3 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 1 p. 27 - 31
反应条件
1: 1.) LiOH; 2.) AcOH / 1.) EtOH, r.t.; 2.) r.t. 2: 80 percent / TFA / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 20 p. 2639 - 2640
反应条件
hydrogenchloride; acetic acid 4 h; Heating;
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
反应条件
1: 85 percent / conc. HCl, glacial AcOH / 4 h / Heating 2: 74 percent / SnCl2, conc. HCl / 1.5 h / Ambient temperature View Scheme
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
反应条件
trifluoroacetic acid in toluene T=80°C; 6 h;
参考文献
Rao, A. V. Rama; Rao, Ramakrishna; Yadav; Khagga, Mukkanti
Synthetic Communications, 2013 , vol. 43, # 12 p. 1661 - 1667
反应条件
toluene-4-sulfonic acid in toluene Heating1) 30 min, 2) 3 h;
参考文献
Ejima, Akio; Terasawa, Hirofumi; Sugimori, Masamichi; Tagawa, Hiroaki
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 1 p. 27 - 31
反应条件
toluene-4-sulfonic acid in toluene 2 h; Heating;
参考文献
Wani; Nicholas; Wall
Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2317 - 2319
反应条件
toluene-4-sulfonic acid in toluene 3 h; Heating;
参考文献
Jew; Ok; Kim; Hah; Cho
Tetrahedron Asymmetry, 1995 , vol. 6, # 6 p. 1245 - 1248
反应条件
1: 85 percent / conc. HCl, glacial AcOH / 4 h / Heating 2: 74 percent / SnCl2, conc. HCl / 1.5 h / Ambient temperature 3: NaNO2, H2SO4 / H2O / 1 h / Heating View Scheme
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
反应条件
hydrogenchloride; acetic acid in ethanol; water T=110 - 115°C; 24 h;
参考文献
SHILPA MEDICARE LTD.
Patent: WO2008/35377 A2, 2008 ;
Location in patent: Page/Page column 10 ;
