3-羟基-3-甲基氮杂环丁烷-1-甲酸叔丁酯合成路线 （共 3 条）
反应条件
1: in diethyl ether T=0 - 20°C; 19.75 h; 2: With ammonium chloride in diethyl ether; water T=20°C;
参考文献
JANSSEN PHARMACEUTICA NV; CARRUTHERS, Nicholas, I.; SHIREMAN, Brock, T.; TRAN, Vi, T.; WONG, Victoria, D.; JABLONOWSKI, Jill, A.; CHAI, Wenying
Patent: WO2010/59393 A1, 2010 ;
Location in patent: Page/Page column 151 ;
WO 2010/059393 A1
反应条件
1: in tetrahydrofuran T=0°C; 1 h; 2: With water; ammonium chloride in tetrahydrofuran
参考文献
Hendricks, Robert Than; Hermann, Johannes; Kondru, Rama; Lou, Yan; Lynch, Stephen M.; Owens, Timothy D.; Soth, Michael
Patent: US2011/230462 A1, 2011 ;
Location in patent: Page/Page column 91 ;
US 20110230462 A1
反应条件
1: With trifluoroacetic acid in dichloromethane T=20°C; 3 h; 2: With ammonia in methanol
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/80682 A1, 2009 ;
Location in patent: Page/Page column 68-69 ;
WO 2009/080682 A1
